What Kind of Trial and How Big: 

• Therapeutic Development  (Steven Piantadosi) (slides only)
• How to Decide When to Bring a Therapy to Trial (assessment of preclinical data) (Tim Cloughesy) (16:26) 
• “Phase 0” and Other Surgical Trials (Ian Parney) (18:46) 
• Phase I Trials (Jennifer Clarke) (14:56) 
• Phase II Trials (Evanthia Galanis) (18:23) 
• Phase III Trials (Martin van den Bent) (22:06) 
• Novel Designs (umbrella, basket, platform, adaptive randomization, external control) (Rif Rahman) (32:33)  

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